Premarin Vaginal Cream could result in more comfortable sex, uterine cancer, heart disease, heart attacks, stroke, dementia, blood clots or breast cancer

Premarin CreamA reader recently confided that she was experiencing painful intercourse after many years of a happy, fulfilling and frequent sex life with her husband. She was also experiencing vaginal itching, burning and irritation. She wanted to address the underlying cause of her lack of lubrication naturally, without resorting to hormone replacement of any kind.

This turns out to be a tall order because the reason she’s having painful intercourse is because she achieved menopause more than a year ago at age 51, and it’s highly likely that her estrogen levels have fallen.

Estrogens are a group of hormones that provide natural lubrication, among other benefits.

My chat with her is probably why a few days later, I noticed an advertisement for Premarin Vaginal Cream in a women’s magazine. This is a cream marketed to post-menopausal women who are experiencing painful intercourse because of declining estrogen levels.

Now, I’ll be very transparent and reveal that I’m a personal-care product label-reader from way back. It’s important to me that I put safe ingredients in me, and on me, not toxic, dangerous chemicals. From experience, I don’t trust manufacturers of shampoos, skin creams and soaps that are typically available in drug stores and grocery stores. I look for products that meet my own health and safety standards – usually in natural food stores or on the Internet.

There are hundreds of products on the market that I consider to be highly unethical and downright dangerous because of their ingredients. I have a strong sense of outrage at the dangerous, cheap garbage that’s presented as high quality, nourishing creams, soaps and lotions.Premarin Cream

The first ‘red light’ that went off for me was the name of this cream: ’Premarin Vaginal Cream’. This is the same name as an oral prescription medication that my mother took for more than 20 years after her hysterectomy. Hmmm. Her pills were made from pregnant horse urine and she stopped using them in 2002 when the results of the nurses’ study revealed a statistical connection between hormone replacement therapy and cancer.

When I saw the Premarin Vaginal Cream advertisement, my first thought was that it looks like the pharmaceutical company loves the name Premarin and has found a new way to make money from cheap horse estrogen. Then I decided to read the product information the company is required to provide. I wanted to find out the consequences you could experience from using a cream that promises to improve your sex life after menopause.

Premarin is basically a mixture of estrogen hormones that are used for treating menopausal symptoms like irritation, burning, vaginal dryness and hot flashes.

Premarin Vaginal Cream Side Effects

We live in a bizarre world where the cost of comfortable sex could be death – and that seems to be an acceptable risk – for Pfizer, the manufacturer of Premarin Vaginal Cream and the thousands of women and their partners who use it.

You will notice that none of the following potential side-effects, including ones noted as ‘less serious’ is an aphrodisiac or will inspire a woman to become interested in having sexual intercourse. In fact, using this cream could reduce your sex drive!!

In the advertisement itself is ‘important safety information’. I can’t imagine the circumstances where a woman would read this and go ahead and buy a tube of Premarin Vaginal Cream.

Ok, so if you use this cream, even the manufacturers admit that you are at risk of…

  • Uterine cancer
  • Stroke
  • Blood clots
  • Breast cancer
  • Heart attack
  • Dementia
  • Gallbladder disease
  • Ovarian cancer
  • High blood pressure
  • Liver problems
  • High blood sugar
  • Enlargement of benign tumors (fibroids)

Premarin CreamWomen are advised not to use Premarin if they have a history of blood clot, stroke, heart attack (or a history), abnormal vaginal bleeding, liver disease and uterine, breast or hormone related cancer. Using this drug can lead to uterine cancer.

Less serious, but common, side effects include:

  • Headache
  • Breast pain
  • Irregular vaginal bleeding or spotting
  • Stomach/abdominal cramps, bloating
  • Nausea and vomiting
  • Hair loss
  • Fluid retention
  • Yeast infection
  • Reactions from inserting Premarin Vaginal Cream such as vaginal burning, irritation and itching (aren’t these the same symptoms this cream is supposed to stop?!?!)

The side-effects list goes on…’concentration or memory problems, confusion, jaundice, lump in breast, swelling of feet, ankles and hands, facial skin darkening or freckles, scalp hair loss, increase in hair growth, changes in appetite or weight, contact lens troubles and vaginal discharge or itching, changes in menstrual periods, tiredness, dizziness, nervousness and headaches.

 Drug Interactions with Premarin Vaginal Cream

When you are prescribed Premarin, make sure you inform your doctor if you take any of the following medications: warfarin (blood thinner), levothyroxine (thyroid medication), diabetes medicine or insulin taken orally, rifampin, ketoconazole, seizure medicines such as primidone, oxcarbazepine, felbamate, carbamazepine and phenytoin. Few other drugs that can interact with Premarin include barbiturate such as Phenobarbital, secobarbital, mephobarbital, butabarbital and amobarbital and antidepressants such as amitriptyline, trimipramine, protriptyline, nortriptyline, imipramine, doxepin, desipramine, clomipramine and amoxapine.

As if that’s not enough to repel you from ever buying a tube of Premarin Vaginal Cream, I researched the non-medicinal ingredients it contains. They include harmless ingredients: white wax, purified water, glycerin, and cetyl esters wax which adds creaminess and ‘glide’. Premarin Vaginal Cream also contains the following scary skin irritants and suspected carcinogens…

  1. sodium lauryl sulfate (SLS) - a cheap, commonly used ingredient in shampoo, liquid soaps and creams, SLS is a known skin irritant that dissolves the oils on your skin. It enters the body and maintains residual levels in the heart, liver, lungs and brain from skin contact. SLS is a xenoestrogen that disrupts the body’s natural hormone levels. SLS in a known mutagen – it is capable of damaging the genetic material found every cell in your body. As mutagenicity has been strongly linked to cancer, this is a major concern re: cancers of the breast and ovaries.
  2. propylene glycol monostearate – Used in antifreeze and de-icing solutions for cars, boats, and aircraft; also used as a solvent for paints and plastics; Cancer link; reproductive, developmental and organ system toxicity found and reported by Environmental Working Group. Skin, eyes and lung sensitizer – can instigate immune system response that can include itching, burning, scaling, hives, and blistering of skin.
  3.  phenylethyl alcohol – an irritant that’s harmful by inhalation, ingestion and through skin absorption.
  4. mineral oil – is a byproduct of the distillation of gasoline from crude oil. It sits on the skin as an unbreathable barrier – clogging pores. Once the oil is absorbed through your skin, it is broken down by the liver and passes through the intestinal tract where it absorbs nutrients there. Over time, this can lead to nutritional deficiencies.
  5. methyl stearate – a hazardous material that causes eye and skin, respiratory and digestive tract irritation. Workers who handle this chemical are advised to ‘avoid contact with eyes, skin and clothing’ and ‘wash hands and face before eating, drinking or smoking.
  6. glyceryl monostearate – mild skin and eye irritant

Now, Premarin Vaginal Cream is marketed as a ‘short term use’ cream ‘that can help you create your own lubrication’…’to treat menopausal changes in and around the vagina and to treat painful intercourse caused by these changes.’

Even though taking Premarin for an extended period of time can increase risks of developing blood clots or stroke, I’d like to know how many women who make the decision to start using this cream would have the discipline to stop using it. In other words, how ‘temporary’ is this cream in actual real-life usage? What are you supposed to use when you stop using Premarin Vaginal Cream?

What can you use instead of Premarin Vaginal Cream?

Commercial vaginal lubricants are sold in tubes, bottles, and as vaginal suppositories at the drugstore and online. There are many different brands, so here’s a ‘shopping list’ to find the best lubricant for you. It should be…

  • water-based
  • non-staining
  • non-toxic
  • latex friendly
  • Ph balanced for the vagina
  • Pleasant tasting or tasteless
  • Provide lubrication that lasts and doesn’t get sticky

Avoid commercial lubricants that contain parabens, preservatives, mineral oil, animal products or petroleum ingredients – including Vaseline and baby oil.

Three brands suggested by Lorna Vanderhaeghe and Dr. Alvin Pettle in their book ‘Sexy Hormones’ include ‘LOVE’ by Preferred Nutrition, ‘Oh My!’ and Emerita.

You may prefer to use nourishing oils that are closer to your body’s own natural oils and are unlikely to create problems inside your vagina. Experiment with natural oils and creams made with cocoa butter or shea butter, oils of olive, coconut, sweet almond, camellia, jojoba (which is actually a wax). These oils have nutrients that are good for your skin and allow it to breathe.

Nutritional suggestions include ground flax seeds and/or Motherwort Tincture.

My opinion? Almost anything that’s clean and has glide is better than Premarin cream.

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Leave A Reply (8 comments so far)


  1. Daina Martek
    5 years ago

    Thank-you!!! My obgyn called in this prescription along with Vivelle dot and I’ve been trying to do research on them. I use to trust every thing and now I trust nothing. And now all I can see is companies want to make money of their product. I’m so new at this, I don’t really have the research down. But I do feel that your article here is the truth. So thank-you, so much.


    • Wendy Vineyard
      5 years ago

      You’re very welcome Daina. Let me know if the suggestions you’ve read on my website help. Vaginal dryness is a problem for many women and their partners. It requires sensitivity, love, patience, and research for the solution that works best for both of you – sort of like the search for birth control! :-)


  2. Lynn Patton
    5 years ago

    Interesting article. I have been going through weeks of being miserable treated for UTI, yeast infection because of sudden I will say discomfort I was feeling ALL of the time not just sex. My OB prescribed to use this cream for a couple weeks every nite. Then back off on doses. I had a partial hysterectomy almost 2 yrs ago. My libido has actually increased but then this irritation I would say came out of nowhere and it’s been a process trying to figure the cause. I’ve used the cream for a few days & I’m starting to “feel” better already which is huge to me. I’m hoping this would maybe ‘balance’ things & maybe I could stop using it. And not continue for a long period. Have u heard if short term usage is problematic ?


    • Wendy Vineyard
      5 years ago

      HI Lynn: Short term usage is what most doctors recommend for any hormone replacement, because it’s a risk management decision that you’ll experience relief before the drug has time to harm you. With any drug there are risks.

      Looking beneath the presenting symptoms of urinary tract infection and yeast infection, both of these conditions say ‘stay away’ re: sexual contact. The body-mind connection to UTIs is about being ‘pissed off’ – most usually at your love partner. Does this fit for you?

      In another direction, have you considered addressing a probable fungal infection in your body, indicated by your difficulty with yeast, with oil of oregano? There’s a supplement company called North American Herb & Spice and they make spice oils and supplements based on wild oil of oregano that can help this problem.

      Check out a few natural food stores for these products and take a look at their website: http://www.p-73.com/. For my fungal infection, I took Fung-E-Clenz – 20 drops twice daily and Juice of Oregano – 1 ounce for several weeks. I stopped eating all sugar and added sweeteners while I was on this protocol. You may also need to take Health Bac, which is probiotics to replenish beneficial bacteria in your gut. Hope this helps. Let me know, ok?


  3. Ione
    4 years ago

    You have some excellent suggestions for a natural way to treat vaginal dryness. However, vaginal dryness is one thing, vaginal atrophy is another. Do you have any suggestions for a natural treatment for the loss of elacticity? Lubricants alone will not help.


    • Wendy Vineyard
      4 years ago

      There are lots of natural options for solving vaginal dryness. Take your pick of a couple of these: Kegel exercises, oatstraw infusion, drink more water, take borage oil daily, collagen supplements, etc. Be consistent and persistent. Meanwhile, use a lubricant without parabens or artificial ingredients. There’s one in Canada called ‘Love Lubricant’ by Lorna Vanderhaeghe. Nice!


  4. kathryn Baker
    3 years ago

    I would never use Premarin because of the cruelty involved with the production of it. Horses do not deserve to be used as living vessels to be confined with a bag on them to remove their urine. they also should not be pregnant with unwanted foals just to produce the appropriate urine. The foals are usually sent to slaughter unless someone rescues them. This is a CRUELTY product.



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